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Phase III Randomized Trial of Hypo-fractionated Post Mastectomy Radiation with Breast Reconstruction
To determine if a shorter course of radiation therapy (3-4 weeks) is as safe and effective as the typical 5 to 6 week treatment course after mastectomy.
DiagnosisInvasive Cancer of the Breast
Planned radiation and re-construction after mastectomy
No prior radiation therapy
No prior history of breast cancer
No other cancers within 5 years prior to registration on this study
Patients must sign an approved informed consent and authorization permitting release of personal health information.
- Radiation Therapy
- Group 1: 5-6 weeks of radiation therapy (usual approach)
- Group 2: 3-4 weeks of hypofractionated radiation therapy
- Quality of Life Questionnaires
All patients enrolled on this trial will receive radiation after mastectomy. All patients will also have breast reconstruction. The reconstruction can be done at the time of the mastectomy before enrollment to the study, or as a separate surgery later.
The study doctor will continue to watch for side effects and follow your condition for 5 years after the completion of radiation therapy.
For more information, visit ClinicalTrials.gov