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GOG-3029/ENGOT-ov50/INNOVATE-3, EF-28

Trial Overview

Official Title

Pivotal, Randomized, Open-Label Study Of Tumor Treating Fields (TTFields, 200khz) Concomitant With Weekly Paclitaxel For The Treatment Of Recurrent Ovarian Cancer

Study Purpose

To compare treatment using TTFields together with standard of care chemotherapy (called Paclitaxel) to standard of care chemotherapy (Paclitaxel) without TTFields. This study will help determine if using TTFields with chemotherapy is better than the usual approach of chemotherapy alone.

Diagnosis

Ovarian cancer that progressed after receiving a platinum-based chemotherapy

Eligibility

Maximum of five prior lines of completed therapy

Must be willing to receive weekly paclitaxel and able to operate the NovoTTF-100L(O) System

Measurable or non-measurable disease in the abdominal/pelvic region

Patients must sign an approved informed consent and authorization permitting release of personal health information.

Intervention

  • Study Device: TTFields, a device that you would carry and wear for at least 18 hours a day that delivers continuous treatment to your disease
  • Group 1: You will receive standard chemotherapy (paclitaxel) associated with TTFields
  • Group 2: You will receive standard chemotherapy (paclitaxel) alone

This study is expected to last 48 months.

For more information, visit ClinicalTrials.gov

Key Participation Requirements
Gender
Female
Age
19 years and older
Phase
Phase III
Methodist Health System Trial Code
GOG-3029/ENGOT-ov50/INNOVATE-3, EF-28