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Calithera Biosciences CX-839-014

Trial Overview

Official Title

A Phase 2 Randomized, Multicenter, Double-Blind Study Of The Glutaminase Inhibitor Telaglenastat With Pembrolizumab And Chemotherapy Versus Placebo With Pembrolizumab And Chemotherapy In First-Line, Metastatic KEAP1/NRF2-Mutated, Non-Squamous, Non-Small Cell Lung Cancer (NSCLC)

Study Purpose

To determine the amount of telaglenastat that is safe and tolerable when given together with the recommended treatment regimen of pembrolizumab, carboplatin, and pemetrexed and to determine if the combination of standard drugs with telaglenastat is more active against your type of cancer than the standard drugs alone.

Diagnosis

Patients have non-small cell lung cancer (NSCLC) that has spread to other areas of the body (metastatic) and have not yet been treated for metastatic disease.

Eligibility

Non-Squamous, Non-Small Cell Lung Cancer

1st line, KEAP1 or NRF2 mutation, ECOG 0-1

Patients must sign an approved informed consent and authorization permitting release of personal health information.

Intervention

Patients will be randomly assigned to take either telaglenastat or placebo plus the standard cancer drugs.

Patients will be included in the safety evaluation period to determine what is the appropriate amount of telaglenastat to give in combination with pembrolizumab, carboplatin, and pemetrexed.

For more information, visit ClinicalTrials.gov

Key Participation Requirements
Gender
Male or Female
Age
19 years and older
Phase
Phase II
Methodist Health System Trial Code
CX-839-014