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Testing Therapy Sequence for Advanced BRAF Mutation Melanoma
To compare the good and bad effects of the sequence of immunotherapy followed by BRAF inhibitor therapy if and when it gets worse.
DiagnosisStage III or IV Melanoma
Melanoma cannot be removed by surgery.
Finished with chemotherapy, immunotherapy, or other therapy by 4 weeks or longer.
Women must not be pregnant or breast feeding.
Patients must sign an approved informed consent and authorization permitting release of personal health information.
- Group 1: Immunotherapy=Ipilimumab and Nivolumab and at Disease Progression BRAF Inhibitor Therapy=Dabrafenib and Trametinib
- Group 2: BRAF Inhibitor Therapy=Dabrafenib and Trametinib and at Disease Progression Immunotherapy=Ipilimumab and Nivolumab
- Quality of Life questionnaires
After completion of the study patients will be followed for 5 years
For more information, visit ClinicalTrials.gov