MUIR-3
Trial Overview
Official Title
DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PLOZASIRAN IN ADULTS WITH HYPERTRIGLYCERIDEMIA (MUIR-3 STUDY)
Study Purpose
To demonstrate the efficacy of plozasiran on reducing fasting serum triglyceride levels.
Diagnosis
Mean triglycerides level ≥ 150 mg/dL and ≤ 499 mg/dL; fasting LDL ≤ 130 mg/dLEligibility
- Willing to follow diet counseling and maintain a stable low-fat diet.
Exclusion - Use of siRNA within the last year aimed at treating triglycerides
- BMI > 45
- Acute pancreatitis within 4 weeks of screening
Intervention
Plozasiran vs placebo
For more information, click the link below:
https://clinicaltrials.gov/study/NCT06347133
Key Participation Requirements
Trial Location(s)
Gender
All
Age
19+
Enrollment Status
Recruiting
Phase
Phase III
Methodist Health System Trial Code
NCT06347133