Decorative dot pattern background image.
Decorative blue shape background image. Decorative blue shape background image. Decorative blue shape background image. Decorative blue shape background image.

MUIR-3

Trial Overview

Official Title

DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PLOZASIRAN IN ADULTS WITH HYPERTRIGLYCERIDEMIA (MUIR-3 STUDY)

Study Purpose

To demonstrate the efficacy of plozasiran on reducing fasting serum triglyceride levels.

Diagnosis

Mean triglycerides level ≥ 150 mg/dL and ≤ 499 mg/dL; fasting LDL ≤ 130 mg/dL

Eligibility

  • Willing to follow diet counseling and maintain a stable low-fat diet.
    Exclusion
  • Use of siRNA within the last year aimed at treating triglycerides
  • BMI > 45
  • Acute pancreatitis within 4 weeks of screening
     

Intervention

Plozasiran vs placebo

For more information, click the link below:

https://clinicaltrials.gov/study/NCT06347133

Key Participation Requirements
Trial Location(s)
Gender
All
Age
19+
Enrollment Status
Recruiting
Phase
Phase III
Methodist Health System Trial Code
NCT06347133
Related Specialties