Heart and Vascular

Official Title: BOLT: A Prospective, Multicenter Study of Patients with Deep Vein Thrombosis to Evaluate the Safety and Efficacy of the Indigo® Aspiration System

Study Purpose: Evaluated Safety and Efficacy of Indigo Aspiration System

Status: Recruiting

Official Title: Post-Market Real World Outcomes in WATCHMAN FLX™ Pro Left Atrial Appendage Closure (LAAC) Device

Study Purpose: The primary objective of this study is to collect real-world outcomes data on WATCHMAN FLX™ Pro Left Atrial Appendage Closure (LAAC) Device in patients who are implanted with the WATCHMAN FLX Pro device in a commercial clinical setting.

Status: Available

Official Title: A randomized trial of ultrasound-facilitated, catheter-directed, thrombolysis versus anticoagulation for acute intermediate-high risk pulmonary embolism: The higher-risk pulmonary embolism thrombolysis study.

Study Purpose: To assess whether ultrasound-facilitated, catheter-directed, thrombolysis and anticoagulation are associated with a significant reduction in the composite outcome of pulmonary embolism (PE)-related mortality, cardiorespiratory decompensation or collapse, or nonfatal symptomatic and objectively confirmed recurrence of PE compared to anticoagulation alone within seven days of randomization.

Status: Recruiting

Official Title: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction (LeAAPS) Trial

Study Purpose: To evaluated safety and effectiveness of prophylactic LAAE for the prevention of ischemic stroke or systemic embolism in subjects undergoing cardiac surgery who have risk factors for AF and ischemic stroke

Status: Recruiting

Official Title: A Phase 3, Randomized, Double-blind, Placebo-controlled, Event-driven Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, After a Recent Acute Coronary Syndrome

Study Purpose: The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major adverse cardiovascular event (MACE) (the composite of cardiovascular [CV] death, myocardial infarction [MI], and ischemic stroke).

Status: Recruiting

Official Title: Left Atrial Posterior Wall Isolation in Conjunction with Pulmonary Vein Isolation Using the Cryoballoon for Treatment of Persistent Atrial Fibrillation (PIVoTAL-IDE) Trial

Study Purpose: To compare cryoballoon ablation with posterior wall isolation to cryoballoon ablation in the treatment of persistent atrial fibrillation and the efficacy over a 12 month time span.

Status: Active, Not Recruiting

Official Title: Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: the ROMA trial

Study Purpose: It is the first cardiac surgery trial dedicated exclusively to women. Patients will be randomized in a 1:1 fashion. Patients will be randomized to a single arterial graft (SAG) or multiple arterial grafts (MAG).

Status: Recruiting

Official Title: Stimulation Of the Left Ventricular Endocardium for Cardiac Resynchronization Therapy in Non-Responders and Previously Untreatable Patients (SOLVE CRT)

Study Purpose: This study is a prospective, multi-center, randomized, controlled, double blinded, pivotal trial to study the safety and efficacy of the WiSE-CRT System for Cardiac Re-synchronization Therapy.

Status: Active, Not Recruiting