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SHASTA-3

Trial Overview

Official Title

DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PLOZASIRAN IN ADULTS WITH SEVERE HYPERTRIGLYCERIDEMIA (SHASTA-3 STUDY)

Study Purpose

To demonstrate the efficacy of plozasiran on reducing fasting serum triglyceride levels.

Diagnosis

Mean triglycerides level ≥ 500 mg/dL; fasting LDL ≤ 130 mg/dL

Eligibility

  • Willing to follow diet counseling and maintain a stable low-fat diet.
    Exclusion
  • Use of siRNA within the last year aimed at treating triglycerides
  • Known familial chylomicronemia syndrome
  • BMI > 45
  • Acute pancreatitis within 4 weeks of screening
     

Intervention

Plozasiran vs placebo

For more information, click the link below:

https://clinicaltrials.gov/study/NCT06347003

Key Participation Requirements
Trial Location(s)
Methodist Physicians Clinic
Gender
All
Age
19+
Enrollment Status
Recruiting
Phase
Phase III
Methodist Health System Trial Code
NCT06347003
Related Specialties