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Clinical Trials Search

As a clinical trial candidate at Methodist, you’re offered unique access to new drugs and technology being studied to improve patient outcomes.
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Showing 1-10 results of 104
Head and Neck Cancer

20-214-36/Nektar Propel-36

Official Title: A Phase 2/3, Randomized, Open-label Study to Compare Bempegaldesleukin Combined with Pembrolizumab Versus Pembrolizumab Alone in First-Line Treatment of Patients with Metastatic or Recurrent Head and Neck Squamous-Cell Carcinoma with PD-L1 Expressing Tumors (PROPEL-36)
Study Purpose: To compare the overall survival and the objective response rate of bempegaldesleukin plus pembrolizumab vs. pembrolizumab monotherapy.
Status: Recruiting
Heart and Vascular

ADVENT-IDE

Official Title: A Prospective Randomized Pivotal Trial of the FARAPULSE Pulsed Field Ablation System Compared With Standard of Care Ablation in Patients With Paroxysmal Atrial Fibrillation
Study Purpose: This is a prospective, adaptive, multi-center, randomized safety and effectiveness pivotal study comparing the FARAPULSE Pulsed Field Ablation System with standard of care ablation with force-sensing RF catheters and cryoballoon catheters indicated for the treatment of PAF.
Status: Active, Not Recruiting
Urinary Cancer

AFT-19

Official Title: A Phase 3 Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer
Study Purpose: To compare progression free survival and overall survival of the standard hormone therapy degarelix verses  degarelix and apalutamide versus degarelix, apalutamide, abiraterone, and prednisone.
Status: Recruiting
Gynecologic Cancer

AFT-50

Official Title: A Phase IB/II Multi-cohort Study of Targeted Agents with Atezolizumab for Patients with Recurrent or Persistent Endometrial Cancer
Study Purpose: To evaluate the efficacy and safety of targeted agents plus cancer immune checkpoint therapy with atezolizumab for patients with recurrent and/or persistent endometrial cancer.
Status: Pending
Breast Cancer

Alliance A011801

Official Title: T-DM1 and Tucatinib Compared With T-DM1 Alone In Preventing Relapses In People With High Risk Her2-Positive Breast Cancer
Study Purpose: To compare the usual treatment with T-DM1 alone to T-DM1 plus tucatinib.
Status: Recruiting
Gastrointestinal Cancer

Alliance A021502

Official Title: Testing the Addition of the Antibody Atezolizumab to Usual Chemotherapy after Surgery in Patients with Colon Cancer
Study Purpose: To compare any good and bad effects of using the drug atezolizumab along with the usual chemotherapy compared to the usual chemotherapy alone.
Status: Recruiting
Gastrointestinal Cancer

Alliance A021602

Official Title: Testing cabozantinib in patients with advanced pancreatic neuroendocrine and carcinoid tumors after progression on everolimus
Study Purpose: The purpose of this study is to learn if treatment with a drug called cabozantinib to prevent tumor growth is better, the same, or worse than placebo (a pill that contains no active drug).
Status: Recruiting
Gastrointestinal Cancer

Alliance A021806

Official Title: Testing The Use Of The Usual Chemotherapy Before And After Surgery For Removable Pancreatic Cancer
Study Purpose: To determine if receiving chemotherapy before and after surgery will increase the chance of pancreatic cancer staying away.
Status: Recruiting
Urinary Cancer

Alliance A031102

Official Title: A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors
Study Purpose: To determine if giving high dose chemotherapy and having a stem cell transplant will prevent or lengthen the time the time to recurrence when compared to the usual treatment of chemotherapy.  
Status: Recruiting
Urinary Cancer

Alliance A031702

Official Title: Testing the effectiveness of two immunotherapy drugs (nivolumab and ipilimumab) with one anti-cancer targeted drug (cabozantinib) for rare genitourinary tumors
Study Purpose: To test the good and bad effects of the drugs cabozantinib, nivolumab, and ipilimumab in rare genitourinary cancers that have no standard treatment options. The doctors hope to learn if the study drugs will stabilize or shrink the cancer.
Status: Recruiting