Clinical Trials Search

Official Title: A PHASE 3 RANDOMIZED, OPEN-LABEL, MULTICENTER CLINICAL STUDY OF CGT9486+SUNITINIB VS SUNITINIB IN SUBJECTS WITH LOCALLY ADVANCED, UNRESECTABLE OR METASTATIC GASTROINTESTINAL STROMAL TUMORS 

Study Purpose: The purpose of this part of the research study is to evaluate how CGT9486 plus sunitinib affects GIST compared to just treatment with sunitinib alone. 

Status: Recruiting

Official Title: The CHRONICLE Study: A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals With Severe Asthma in the United States

Study Purpose: The CHRONICLE Study is a multi-center, non-interventional, prospective cohort study of adults with severe asthma who do not achieve control with high-dose inhaled corticosteroid (ICS) therapy with additional controllers and/or require systemic corticosteroid or monoclonal antibody therapy. Data will be collected from the healthcare provider in a uniform manner for every patient enrolled using an electronic case report form (eCRF). Data will be collected monthly from patients via web-based surveys. Patients will be followed until study discontinuation or the patient withdraws from the study or death, whichever occurs first. The expectation is that patients will be followed for a period of at least 3 years.

Status: Recruiting

Official Title: Center for International Blood and Marrow Transplant Research: Protocol for a Research Database for Hematopoietic Cell Transplantation and Cellular Therapies

Study Purpose: To gather health information from patients receiving stem cell transplants that can be used to find ways to make stem cell transplants work better. 

Status: Recruiting

Official Title: A Phase 3, multicenter, double-blind, randomized, placebo-controlled study of ivosidenib in participants ≥18 years of age with locally advanced or metastatic conventional chondrosarcoma with an IDH1 mutation, untreated or previously treated with 1 systemic treatment regimen

Study Purpose: To assess how well the drug Ivosidenib works against chondrosarcoma

Status: Pending

Official Title: A Phase II, Single-Arm Study of Giredestrant in Patients with Grade 1 Endometrial Cancer

Study Purpose: To assess the efficacy, safety, and pharmacokinetics of giredestrant in participants with Grade 1 endometrioid endometrial carcinoma.

Status: Recruiting

Official Title: Targeted Treatment for Advanced Non-small Cell Lung Cancer

Study Purpose: To find out if a targeted or immunotherapy treatment will have an effect on specific genes and proteins in the tumor.

Status: Recruiting

Official Title: Testing Whether the Of Brain Scans Alone Instead Of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients with Small Cell Lung Cancer

Study Purpose: To see if the use of brain scans alone instead of brain scans plus preventive brain radiation affect the lifespan of patients with small cell lung cancer.

Status: Recruiting

Official Title: APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Study Purpose: To see if treating with olaparib compared to the usual approach which is observation,  is more successful in preventing pancreatic cancer from coming back 

Status: Recruiting

Official Title: Study Lower-Dose Chemoradiation for Early-Stage Anal Cancer

Study Purpose: To compare lower-dose chemoradiation therapy to standard-dose chemoradiation therapy and to find out if this approach is better or worse than the usual approach for anal cancer.

Status: Recruiting

Official Title: Testing The Addition Of Chemotherapy Drug, Cisplatin, To Usual Radiation Therapy For Patients With Head And Neck Cancer

Study Purpose: To compare two treatment approaches currently used after surgery for head and neck cancer. One approach is to administer radiation therapy alone.  A second approach is to administer radiation therapy along with the chemotherapy drug, cisplatin.

Status: Suspended