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Clinical Trials Search

As a clinical trial candidate at Methodist, you’re offered unique access to new drugs and technology being studied to improve patient outcomes.
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Showing 1-10 results of 12
Gynecologic Cancer

AFT-50

Official Title: A Phase IB/II Multi-cohort Study of Targeted Agents with Atezolizumab for Patients with Recurrent or Persistent Endometrial Cancer
Study Purpose: To evaluate the efficacy and safety of targeted agents plus cancer immune checkpoint therapy with atezolizumab for patients with recurrent and/or persistent endometrial cancer.
Status: Recruiting
Gynecologic Cancer

GOG-3035/OncoQuest QPT-ORE-005/FLORA-5

Official Title: A Phase 3, Double-Blind, Placebo-Controlled, Multicenter Clinical Study comparing Chemo-Immunotherapy (Paclitaxel – Carboplatin - Oregovomab) versus Chemotherapy (Paclitaxel-Carboplatin-Placebo) In Patients with Advanced Epithelial Ovarian, Fallopian Tube or Peritoneal Carcinoma
Study Purpose: To see how safe and effective four doses of the experimental drug oregovomab is given at the same time as specific cycles of the chemotherapy regimen paclitaxel and carboplatin.
Status: Recruiting
Gynecologic Cancer

GOG-3044/LAE002INT2001

Official Title: An Open-Label Randomized Active- Controlled Phase Ii Clinical Study To Assess The Efficacy And Safety Of Afuresertib Plus Paclitaxel Versus Paclitaxel In Patients With Platinum-Resistant Ovarian Cancer
Study Purpose: To evaluate the efficacy of afuresertib in combination with paclitaxel when compared to paclitaxel alone in patients with platinum-resistant ovarian cancer.
Status: Recruiting
Gynecologic Cancer

Gradalis CL-PTL-135

Official Title: Blood and Tissue Procurement Protocol for Product Development and Research
Study Purpose: To collect cancerous tissue/fluid and blood samples to store and use for research purposes.
Status: Recruiting
Gynecologic Cancer

InterVenn OVACA-001

Official Title: Clinical Validation of the InterVenn Ovarian Cancer Liquid Biopsy: VOCAL Study
Study Purpose: To evaluate the clinical performance for the InterVenn Ovarian Cancer Liquid Biopsy by collecting and storing blood samples and characterizing protein biomarkers in the blood of cancer vs. non-cancer patients.
Status: Recruiting
Gynecologic Cancer

NRG CC008

Official Title: A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers [SOROCk]
Study Purpose: The purpose of the study is to compare two surgical procedures and their ability to decrease the risk of developing ovarian cancer for pre-menopausal women with BRCA1 mutations.
Status: Recruiting
Gynecologic Cancer

NRG GY012

Official Title: Randomized Phase II Study Comparing Single-Agent Olaparib, Single Agent Cediranib, and the Combinations of Cediranib/Olaparib, Olaparib/Durvalumab (MEDI4736), Cediranib/Durvalumab (MEDI4736), Olaparib/AZD5363 (Capivasertib) in Women with Recurrent, Persistent or Metastatic Endometrial Cancer.
Study Purpose: To compare the safety and effects of cediranib alone, combinations of olaparib with AZD5363 (capivasertib), or durvalumab (MEDI4736) or the combination of cediranib and durvalumab (MEDI4736).
Status: Recruiting
Gynecologic Cancer

NRG GY014

Official Title: A phase II study of tazemetostat (EPZ-6438) (IND#138671) in recurrent or persistent endometrioid or clear cell carcinoma of the ovary, and recurrent or persistent endometrioid endometrial adenocarcinoma
Study Purpose: To find out if this approach is better or worse than the usual approach for your ovarian or endometrial cancer. 
Status: Suspended
Gynecologic Cancer

NRG GY018

Official Title: Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Endometrial Cancer.
Study Purpose: The purpose of this study is to compare any good and bad effects of adding immunotherapy drugs to the usual combination of chemotherapy drugs.
Status: Recruiting
Gynecologic Cancer

NRG GY019

Official Title: A Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole versus Letrozole Monotherapy in Patients with Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum
Study Purpose: To determine how well the oral drug Letrozole works with or without Paclitaxel and Carboplatin in treating stage II-IV low grade cancer of the ovary or peritoneum.
Status: Recruiting