Gastrointestinal Cancer

Official Title: RANDOMIZED PHASE III TRIAL OF MFOLFIRINOX +/- NIVOLUMAB VS. FOLFOX +/- NIVOLUMAB FOR FIRST-LINE TREATMENT OF METASTATIC HER2-NEGATIVE GASTROESOPHAGEAL ADENOCARCINOMA

Study Purpose: To determine if overall survival (OS) is improved in patients who received mFOLFIRINOX +/- nivolumab in comparison to FOLFOX +/- nivolumab as first-line chemotherapy for metastatic gastroesophageal adenocarcinoma

Status: Recruiting

Official Title: PHASE 2 RANDOMIZED TRIAL OF NEOADJUVANT OR PALLIATIVE CHEMOTHERAPY WITH OR WITHOUT IMMUNOTHERAPY FOR PERITONEAL MESOTHELIOMA

Study Purpose: To determine whether frontline treatment with carboplatin, pemetrexed, bevacizumab and atezolizumab results in a superior best response rate than carboplatin, pemetrexed and bevacizumab in patients with peritoneal mesothelioma

Status: Available

Official Title: Testing The Use Of The Usual Chemotherapy Before And After Surgery For Removable Pancreatic Cancer

Study Purpose: To determine if receiving chemotherapy before and after surgery will increase the chance of pancreatic cancer staying away.

Status: Recruiting

Official Title: Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blinded Placebo-Controlled Phase II to Phase III Study.

Study Purpose: To determine if duloxetine prevent numbness, tingling, and/or pain caused by your cancer treatment with oxaliplatin.

Status: Suspended

Official Title: Study Lower-Dose Chemoradiation for Early-Stage Anal Cancer

Study Purpose: To compare lower-dose chemoradiation therapy to standard-dose chemoradiation therapy and to find out if this approach is better or worse than the usual approach for anal cancer.

Status: Recruiting

Official Title: Testing Combination Chemotherapy with or without an Investigational Drug or the Investigational Drug Alone for Metastatic Colon or Rectal Cancer

Study Purpose: To learn if adding the experimental agent atezolizumab (MPDL3280A) to the usual treatment or giving the experimental agent alone is better than the usual treatment alone for metastatic colon or rectal cancer.

Status: Recruiting

Official Title: Using Cancer Cells In the Blood (Ctdna) To Predict If Chemotherapy Will Benefit Patients Who Have Surgery for Early Stage Colon Cancer

Study Purpose: To learn if a ctDNA test done after your surgery for colon cancer is helpful to decide if you should receive chemotherapy.

Status: Suspended

Official Title: A testing the addition of pembrolizumab, an immunotherapy cancer drug to olaparib alone as therapy for patients with pancreatic cancer that has spread with unhealthy tumor suppressor genes.

Study Purpose: To compare the usual treatment alone to using pembrolizumab plus the usual treatment.

Status: Recruiting

Official Title: Phase 2 Study of ZW25 Plus First-line Combination Chemotherapy in HER2-Expressing Gastroesophageal Adenocarcinoma (GEA), Biliary Tract Cancer (BTC), And Colorectal Cancer (CRC) 

Study Purpose: To determine if the experimental study drug ZW25 is safe and effective in the treatment of HER2-expressing GI cancers

Status: Recruiting