Gastrointestinal Cancer

Official Title: Testing the Addition of the Antibody Atezolizumab to Usual Chemotherapy after Surgery in Patients with Colon Cancer

Study Purpose: To compare any good and bad effects of using the drug atezolizumab along with the usual chemotherapy compared to the usual chemotherapy alone.

Status: Recruiting

Official Title: Testing cabozantinib in patients with advanced pancreatic neuroendocrine and carcinoid tumors after progression on everolimus

Study Purpose: The purpose of this study is to learn if treatment with a drug called cabozantinib to prevent tumor growth is better, the same, or worse than placebo (a pill that contains no active drug).

Status: Recruiting

Official Title: Testing The Use Of The Usual Chemotherapy Before And After Surgery For Removable Pancreatic Cancer

Study Purpose: To determine if receiving chemotherapy before and after surgery will increase the chance of pancreatic cancer staying away.

Status: Recruiting

Official Title: Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blinded Placebo-Controlled Phase II to Phase III Study.

Study Purpose: To determine if duloxetine prevent numbness, tingling, and/or pain caused by your cancer treatment with oxaliplatin.

Status: Recruiting

Official Title: Study Lower-Dose Chemoradiation for Early-Stage Anal Cancer

Study Purpose: To compare lower-dose chemoradiation therapy to standard-dose chemoradiation therapy and to find out if this approach is better or worse than the usual approach for anal cancer.

Status: Recruiting

Official Title: Testing the Combination of Pevonedistat With Chemotherapy For Bile Duct Cancer Of The Liver

Study Purpose: To determine if the study drug, pevonedistat alone or pevonedistat in combination with carboplatin and paclitaxel is more efficient in shrinking your cancer.  

Status: Suspended

Official Title: Testing Combination Chemotherapy with or without an Investigational Drug or the Investigational Drug Alone for Metastatic Colon or Rectal Cancer

Study Purpose: To learn if adding the experimental agent atezolizumab (MPDL3280A) to the usual treatment or giving the experimental agent alone is better than the usual treatment alone for metastatic colon or rectal cancer.

Status: Recruiting

Official Title: Using Cancer Cells In the Blood (Ctdna) To Predict If Chemotherapy Will Benefit Patients Who Have Surgery for Early Stage Colon Cancer

Study Purpose: To learn if a ctDNA test done after your surgery for colon cancer is helpful to decide if you should receive chemotherapy.

Status: Recruiting

Official Title: A testing the addition of pembrolizumab, an immunotherapy cancer drug to olaparib alone as therapy for patients with pancreatic cancer that has spread with unhealthy tumor suppressor genes.

Study Purpose: To compare the usual treatment alone to using pembrolizumab plus the usual treatment.

Status: Recruiting

Official Title: Phase 2 Study of ZW25 Plus First-line Combination Chemotherapy in HER2-Expressing Gastroesophageal Adenocarcinoma (GEA), Biliary Tract Cancer (BTC), And Colorectal Cancer (CRC) 

Study Purpose: To determine if the experimental study drug ZW25 is safe and effective in the treatment of HER2-expressing GI cancers

Status: Recruiting