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Head and Neck Cancer

Head and Neck Cancer

20-214-36/Nektar Propel-36

Official Title: A Phase 2/3, Randomized, Open-label Study to Compare Bempegaldesleukin Combined with Pembrolizumab Versus Pembrolizumab Alone in First-Line Treatment of Patients with Metastatic or Recurrent Head and Neck Squamous-Cell Carcinoma with PD-L1 Expressing Tumors (PROPEL-36)
Study Purpose: To compare the overall survival and the objective response rate of bempegaldesleukin plus pembrolizumab vs. pembrolizumab monotherapy.
Status: Recruiting
Head and Neck Cancer

AbbVie M19-894

Official Title: A Phase 1B, Multicenter, Open-Label Study To Determine The Safety, Tolerability, Pharmacokinetics, And Preliminary Efficacy Of Abbv-368 Plus Tilsotolimod And Other Therapy Combinations In Subjects With Recurrent/Metastatic Head And Neck Squamous Cell Carcinoma
Study Purpose: This study will evaluate the effect the combination therapies have on the patient’s body and evaluate the tumor activity and use biomarker tests and imaging results to determine the effects of the combination therapy the patients are assigned to.
Status: Recruiting
Head and Neck Cancer

CMP-001-007

Official Title: A Multicenter Phase 2, Open Label Study Of Intratumoral CMP-001 In Combination With Intravenous Pembrolizumab In Subjects With Recurrent Or Metastatic Head And Neck Squamous Cell Carcinoma
Study Purpose: To determine the safety and efficacy of the study drug, CMP-001, when given in combination with pembrolizumab.
Status: Recruiting
Head and Neck Cancer

EA3191

Official Title: Testing What Happens When An Immunotherapy Drug (Pembrolizumab) Is Added To Radiation Or Given By Itself Compared To The Usual Treatment Of Chemotherapy With Radiation After You Have Had Surgery For Your Recurrent Squamous Cell Carcinoma Of The Head And Neck
Study Purpose: To compare usual approach (chemotherapy plus radiation) to pembrolizumab alone and pembrolizumab in combination with radiation after having head and neck cancer surgically removed.
Status: Recruiting
Head and Neck Cancer

ECOG-ACRIN EA3132

Official Title: Testing The Addition Of Chemotherapy Drug, Cisplatin, To Usual Radiation Therapy For Patients With Head And Neck Cancer
Study Purpose: To compare two treatment approaches currently used after surgery for head and neck cancer. One approach is to administer radiation therapy alone.  A second approach is to administer radiation therapy along with the chemotherapy drug, cisplatin.
Status: Recruiting
Head and Neck Cancer

MacroGenics CP-MGC018-01

Official Title: A Phase 1/2, First-In-Human, Open-Label, Dose-Escalation Study Of MGC018 (Anti–B7-H3 Antibody Drug Conjugate) Alone And In Combination With Mga012 (Anti–PD-1 Antibody) In Patients With Advanced Solid Tumors
Study Purpose: To evaluate the safety and effectiveness of the test drug, MGC018.
Status: Recruiting
Head and Neck Cancer

MECC HN01 - HPV De-escalated Protocol

Official Title: De-escalation Protocol of HPV Mediated Oropharyngeal Squamous Cell Carcinoma Based on the American Joint Committee on Cancer Care (AJCC) 8th Edition Staging Manual
Study Purpose: HPV positive head and neck cancer has been shown to respond very well to treatment and, as a result, the head and neck cancer staging system was updated to better reflect how HPV cancers respond to treatment.  The purpose of this study is to evaluate the effects of treating patients with Human Papilloma Virus (HPV) positive head and neck cancer with less treatment based on the updated head and neck cancer staging system.
Status: Recruiting
Head and Neck Cancer

NRG HN001

Official Title: Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)
Study Purpose: To compare the standard treatment for nasopharyngeal cancer with the drug combination gemcitabine and paclitaxel.  This is also testing if directing treatment using a blood test to look for the Epstien Bar Virus will result in patients doing better and not needing as much treatment.
Status: Recruiting
Head and Neck Cancer

NRG HN006

Official Title: Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity CancerRandomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer
Study Purpose: To see if neck and shoulder function and pain are better after SLN biopsy surgery compared to the usual approach and to see if SLN biopsy surgery is as good as the usual approach in extending your time without cancer.
Status: Recruiting